{"product_id":"new-product-570238","title":"PKA Alpha\/Beta\/Gamma cat Polyclonal Antibody","description":"\u003cp\u003ePRKACA encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of PRKACA caused either by somatic mutations, or genomic duplications of regions that include PRKACA, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.\u003c\/p\u003e\n\u003cp\u003eThe PKD1\/2\/3 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of protein kinase D1, D2, and D3. This antibody is produced using a polyclonal approach, ensuring a high degree of specificity and sensitivity. The PKD1\/2\/3 Polyclonal Antibody is suitable for use in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence. This antibody is ideal for researchers and scientists who require a reliable and accurate tool for the detection of PKD1, D2, and D3 in their experiments. The PKD1\/2\/3 Polyclonal Antibody is manufactured to the highest standards of quality and purity, ensuring consistent and reproducible results. With its exceptional performance and versatility, the PKD1\/2\/3 Polyclonal Antibody is an essential tool for any laboratory conducting research in the field of protein kinase D signaling.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542592995608,"sku":"BT-AP07204","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_eb2b6f26-803f-463f-9f8e-3cb29cb10319.png?v=1705634502","url":"https:\/\/danabiosci.com\/products\/new-product-570238","provider":"Dana Bioscience","version":"1.0","type":"link"}