{"product_id":"new-product-570234","title":"PKA II Beta reg Polyclonal Antibody","description":"\u003cp\u003ecAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. Protein kinase cAMP-dependent type II regulatory subunit beta encoded by PRKAR2B is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.\u003c\/p\u003e\n\u003cp\u003eThe PKC Delta Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of protein kinase C delta (PKC delta) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human PKC delta. The resulting polyclonal antibody has been purified using protein A affinity chromatography and is suitable for use in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe PKC Delta Polyclonal Antibody has been extensively validated for its specificity and sensitivity in detecting PKC delta in various cell lines and tissues. It has been shown to recognize a single band of the expected molecular weight in Western blotting and to produce strong and specific staining in immunohistochemistry and immunofluorescence assays. This antibody is also highly reproducible, with consistent results obtained across multiple experiments.\u003cbr\u003e\u003cbr\u003eIn addition to its high specificity and sensitivity, the PKC Delta Polyclonal Antibody is also highly versatile. It has been successfully used in a wide range of applications, including studies of PKC delta function in cancer, inflammation, and cardiovascular disease. Its high quality and reliability make it an ideal choice for researchers seeking to investigate the role of PKC delta in various biological processes.\u003cbr\u003e\u003cbr\u003eOverall, the PKC Delta Polyclonal Antibody is a valuable tool for researchers studying PKC delta and its role in various biological processes. Its high specificity, sensitivity, and versatility make it an ideal choice for a wide range of applications, and its consistent performance ensures reliable and reproducible results.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542592602392,"sku":"BT-AP07200","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_b4172d22-7781-4507-86dd-8e5063b5c122.png?v=1705634483","url":"https:\/\/danabiosci.com\/products\/new-product-570234","provider":"Dana Bioscience","version":"1.0","type":"link"}