{"product_id":"new-product-569997","title":"p53 Polyclonal Antibody","description":"\u003cp\u003eTP53 encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The tumor protein p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).\u003c\/p\u003e\n\u003cp\u003eThe P53 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of the P53 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human P53 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the P53 protein, making it an ideal tool for a wide range of applications in research and diagnostics.\u003cbr\u003e\u003cbr\u003eThe P53 Polyclonal Antibody is suitable for use in various immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been validated for use in human, mouse, and rat samples, and has been shown to detect both wild-type and mutant forms of the P53 protein. The antibody is supplied as a purified IgG fraction, and is available in various formats and sizes to meet the needs of different applications.\u003cbr\u003e\u003cbr\u003eThe P53 Polyclonal Antibody is manufactured to the highest quality standards, ensuring consistent performance and reproducibility. It is rigorously tested for purity, specificity, and sensitivity, and is guaranteed to provide reliable and accurate results. With its high specificity and sensitivity, the P53 Polyclonal Antibody is an essential tool for researchers and clinicians studying the role of P53 in cancer and other diseases.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542551052568,"sku":"BT-AP06815","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_692c61a7-c593-4c07-9374-aa573fb73ca9.png?v=1705633160","url":"https:\/\/danabiosci.com\/products\/new-product-569997","provider":"Dana Bioscience","version":"1.0","type":"link"}