{"product_id":"new-product-569990","title":"p53 (Acetyl Lys381) Polyclonal Antibody","description":"\u003cp\u003eTP53 (tumor protein p53) encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons.\u003c\/p\u003e\n\u003cp\u003eThe p53 (Acetyl Lys381) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of p53 protein acetylated at Lysine 381. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity for the target protein. \u003cbr\u003e\u003cbr\u003eThe p53 protein plays a crucial role in regulating cell cycle progression, DNA repair, and apoptosis. Acetylation of p53 at Lysine 381 has been shown to enhance its transcriptional activity and stability, making it an important post-translational modification for studying p53 function. \u003cbr\u003e\u003cbr\u003eThis polyclonal antibody has been extensively validated for various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits excellent performance in detecting endogenous levels of acetylated p53 in various cell and tissue types. \u003cbr\u003e\u003cbr\u003eWith its superior sensitivity and specificity, the p53 (Acetyl Lys381) Polyclonal Antibody is an invaluable tool for researchers studying the role of p53 acetylation in cancer, aging, and other cellular processes. Its reliable performance and reproducibility make it an ideal choice for both basic research and clinical applications. \u003cbr\u003e\u003cbr\u003eOrder your p53 (Acetyl Lys381) Polyclonal Antibody today and unlock new insights into the intricate mechanisms of p53 regulation and its impact on cellular homeostasis.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542550495512,"sku":"BT-AP06802","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_779fcb41-00bb-46ee-9c8d-80d6c10d2ebe.png?v=1705633117","url":"https:\/\/danabiosci.com\/products\/new-product-569990","provider":"Dana Bioscience","version":"1.0","type":"link"}