{"product_id":"new-product-569986","title":"p53 (Acetyl Lys320) Polyclonal Antibody","description":"\u003cp\u003eTP53 encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains.Tumor protein p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of TP53 and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).\u003c\/p\u003e\n\u003cp\u003eThe p53 (Acetyl Lys320) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of p53 protein acetylated at Lys320. This antibody is produced using advanced immunization techniques and exhibits exceptional affinity and selectivity towards the acetylated form of p53 at Lys320. \u003cbr\u003e\u003cbr\u003eThe p53 protein plays a crucial role in regulating cell cycle progression, DNA repair, and apoptosis. Acetylation of p53 at Lys320 has been shown to enhance its transcriptional activity and stability, thereby influencing its tumor suppressor function. The p53 (Acetyl Lys320) Polyclonal Antibody enables researchers to investigate the acetylation status of p53 at Lys320 in various biological samples, including cell lysates and tissue sections.\u003cbr\u003e\u003cbr\u003eThis antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunohistochemistry. It exhibits minimal cross-reactivity with other acetylated lysine residues and non-acetylated p53 protein, ensuring accurate and reliable results.\u003cbr\u003e\u003cbr\u003eThe p53 (Acetyl Lys320) Polyclonal Antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It is recommended for use in both basic research and clinical applications, including cancer biology, drug discovery, and biomarker identification.\u003cbr\u003e\u003cbr\u003eIn summary, the p53 (Acetyl Lys320) Polyclonal Antibody is a valuable tool for investigating the acetylation status of p53 at Lys320. Its high specificity, sensitivity, and versatility make it an essential component in various research and diagnostic settings.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542549512472,"sku":"BT-AP06798","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_fdee5bec-a9f3-4498-9651-36de098be295.png?v=1705633098","url":"https:\/\/danabiosci.com\/products\/new-product-569986","provider":"Dana Bioscience","version":"1.0","type":"link"}