p14 Polyclonal Antibody

CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by CDKN2A, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. CDKN2A is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

The P14 Polyclonal Antibody is a highly specialized and meticulously developed product that offers exceptional performance in various scientific applications. This antibody is derived from a diverse pool of B cells, ensuring a broad spectrum of reactivity and enhanced sensitivity. With its superior affinity and specificity, the P14 Polyclonal Antibody is an invaluable tool for researchers and scientists in the fields of immunology, molecular biology, and biochemistry.

The P14 Polyclonal Antibody exhibits remarkable versatility, making it suitable for a wide range of experimental techniques, including Western blotting, immunohistochemistry, and immunofluorescence. Its exceptional sensitivity allows for the detection of even low-abundance target proteins, enabling accurate and reliable results. Moreover, this antibody demonstrates excellent reproducibility, ensuring consistent performance across multiple experiments.

Crafted with utmost precision, the P14 Polyclonal Antibody undergoes rigorous quality control measures to guarantee its purity, stability, and functionality. It is produced using state-of-the-art techniques and adheres to the highest industry standards. Each batch is meticulously tested to ensure optimal performance, providing researchers with the utmost confidence in their experimental outcomes.

The P14 Polyclonal Antibody is supplied in a convenient and user-friendly format, allowing for easy handling and storage. It is provided in a ready-to-use solution, eliminating the need for time-consuming preparation. Additionally, this antibody is available in various sizes to accommodate different experimental requirements.

In summary, the P14 Polyclonal Antibody is a superior product that offers exceptional performance, versatility, and reliability. Its broad reactivity, enhanced sensitivity, and outstanding specificity make it an indispensable tool for researchers seeking accurate and reproducible results in their scientific endeavors.