{"product_id":"new-product-569525","title":"NF-L Polyclonal Antibody","description":"\u003cp\u003eNeurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe NF-L Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of neurofilament light chain (NF-L) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human NF-L protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and is suitable for use in various applications, including Western blotting, immunohistochemistry, and ELISA.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eThe NF-L Polyclonal Antibody has been extensively validated for its specificity and sensitivity in detecting NF-L protein in various tissues and cell types. It has been shown to recognize both human and mouse NF-L protein with high affinity and specificity. This antibody has also been shown to be highly sensitive, with a detection limit of 0.1 ng\/mL in ELISA assays.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eThe NF-L Polyclonal Antibody is a valuable tool for researchers studying neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. It can be used to detect changes in NF-L protein levels in biological samples, which may be indicative of disease progression or response to treatment. Additionally, this antibody can be used to study the role of NF-L protein in neuronal development and function.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eOverall, the NF-L Polyclonal Antibody is a reliable and high-quality antibody that is suitable for a wide range of applications in neuroscience research. Its specificity, sensitivity, and versatility make it an essential tool for researchers studying the role of NF-L protein in health and disease.\u003c\/span\u003e\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542442492184,"sku":"BT-AP05965","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_e4f29eaf-80ef-4d50-8438-01e969585ccf.png?v=1705630633","url":"https:\/\/danabiosci.com\/products\/new-product-569525","provider":"Dana Bioscience","version":"1.0","type":"link"}