{"product_id":"new-product-569522","title":"NF-E4 (Acetyl Lys43) Polyclonal Antibody","description":"\u003cp\u003eThe erythroid-specific protein encoded by NFE4, and the ubiquitous transcription factor CP2, form the stage selector protein(SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG(CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform(22 kDa) acts as an activator, the short isoform(14 kDa) has been shown to repress gamma-globin gene expression. NFE4 is located in an intron of the FBXL13 gene on the opposite strand.\u003c\/p\u003e\n\u003cp\u003eThe NF-E4 (Acetyl Lys43) Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of NF-E4 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the acetylated lysine 43 of the NF-E4 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.\u003c\/p\u003e\n\u003cdiv class=\"product-item--price\"\u003eThe NF-E4 protein is a transcription factor that plays a crucial role in the regulation of gene expression during erythropoiesis. The acetylation of lysine 43 of the NF-E4 protein has been shown to enhance its transcriptional activity, making it an important target for research in the field of hematopoiesis. The NF-E4 (Acetyl Lys43) Polyclonal Antibody has been validated for use in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThis antibody has been extensively characterized for its specificity and sensitivity, ensuring reliable and reproducible results. It has been shown to recognize the acetylated lysine 43 of the NF-E4 protein with high affinity and specificity, while exhibiting minimal cross-reactivity with other proteins. The NF-E4 (Acetyl Lys43) Polyclonal Antibody is an essential tool for researchers studying the role of NF-E4 in erythropoiesis and other biological processes.\u003c\/div\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542442328344,"sku":"BT-AP05959","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_6ef810f9-badd-4653-b961-d47a5fd3aa4e.png?v=1705630621","url":"https:\/\/danabiosci.com\/products\/new-product-569522","provider":"Dana Bioscience","version":"1.0","type":"link"}