{"product_id":"new-product-569223","title":"Mnk2 Polyclonal Antibody","description":"\u003cp\u003eMKNK2 encodes a member of the calcium\/calmodulin-dependent protein kinases (CAMK) Ser\/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization.\u003c\/p\u003e\n\u003cp\u003eThe Mnk2 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of Mnk2 protein expression in various biological samples. This antibody has been extensively validated and exhibits exceptional sensitivity and specificity, ensuring accurate and reproducible results.\u003cbr\u003e\u003cbr\u003eThe Mnk2 Polyclonal Antibody is produced using state-of-the-art techniques, guaranteeing high purity and batch-to-batch consistency. It has been rigorously tested for cross-reactivity with other proteins to ensure its specificity for Mnk2. This antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eWith its superior performance characteristics, the Mnk2 Polyclonal Antibody is an invaluable tool for researchers studying the role of Mnk2 in cellular signaling pathways, protein translation, and cancer biology. Its versatility and reliability make it an essential component of any laboratory involved in protein expression analysis.\u003cbr\u003e\u003cbr\u003eOrder the Mnk2 Polyclonal Antibody today and experience the exceptional quality and performance that this product offers.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542228648216,"sku":"BT-AP05497","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_273dd89d-ec1a-4027-84a5-a531d571bd00.png?v=1705629050","url":"https:\/\/danabiosci.com\/products\/new-product-569223","provider":"Dana Bioscience","version":"1.0","type":"link"}