{"product_id":"new-product-569180","title":"MKP-1\/2 Polyclonal Antibody","description":"\u003cp\u003eDual specificity protein phosphatase 4 encoded by DUSP14 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine\/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK\/ERK, SAPK\/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.\u003c\/p\u003e\n\u003cp\u003eThe MKP-1\/2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of mitogen-activated protein kinase phosphatase 1 and 2 (MKP-1\/2) in various biological samples. This antibody is produced using state-of-the-art techniques, ensuring high purity and quality.\u003cbr\u003e\u003cbr\u003eMKP-1\/2 are key regulators of the mitogen-activated protein kinase (MAPK) signaling pathway, which plays a crucial role in cellular processes such as proliferation, differentiation, and apoptosis. Dysregulation of this pathway has been implicated in various diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions.\u003cbr\u003e\u003cbr\u003eThe MKP-1\/2 Polyclonal Antibody exhibits exceptional specificity, binding exclusively to MKP-1\/2 proteins without cross-reactivity to other related proteins. This specificity allows for accurate and reliable detection of MKP-1\/2 in complex biological samples.\u003cbr\u003e\u003cbr\u003eFurthermore, this antibody demonstrates high sensitivity, enabling the detection of low levels of MKP-1\/2 with minimal sample input. This sensitivity is crucial for studying the dynamic regulation of MKP-1\/2 expression and activity in response to various stimuli or disease conditions.\u003cbr\u003e\u003cbr\u003eThe MKP-1\/2 Polyclonal Antibody is suitable for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated in various cell lines and tissues, ensuring consistent and reproducible results.\u003cbr\u003e\u003cbr\u003eIn summary, the MKP-1\/2 Polyclonal Antibody is a reliable and powerful tool for researchers studying the role of MKP-1\/2 in cellular signaling pathways and disease processes. Its high specificity, sensitivity, and versatility make it an essential component of any research project aiming to elucidate the intricate mechanisms underlying MAPK signaling.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542220620056,"sku":"BT-AP05442","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_ec2edfad-62fc-45ad-87ee-e66dd2c9622a.png?v=1705628838","url":"https:\/\/danabiosci.com\/products\/new-product-569180","provider":"Dana Bioscience","version":"1.0","type":"link"}