{"product_id":"new-product-569179","title":"MKP-1 Polyclonal Antibody","description":"\u003cp\u003eThe expression of DUSP1 gene is induced in human skin fibroblasts by oxidative\/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr\/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.\u003c\/p\u003e\n\u003cp\u003eThe MKP-1 Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of MKP-1 protein levels in various biological samples. This antibody has been rigorously tested and validated for its performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting applications.\u003cbr\u003e\u003cbr\u003eMKP-1, also known as dual specificity phosphatase 1 (DUSP1), is a key regulator of cellular signaling pathways involved in inflammation, stress response, and cell proliferation. Dysregulation of MKP-1 has been implicated in various diseases, including cancer, autoimmune disorders, and neurodegenerative conditions. Therefore, accurate measurement of MKP-1 protein levels is crucial for understanding its role in disease pathogenesis and for the development of targeted therapeutic interventions.\u003cbr\u003e\u003cbr\u003eThe MKP-1 Polyclonal Antibody has been produced using state-of-the-art techniques to ensure high specificity and sensitivity. It has been affinity-purified using recombinant MKP-1 protein, resulting in a highly pure antibody preparation with minimal cross-reactivity to other proteins. This antibody exhibits excellent performance in various experimental conditions, including different tissue types and species.\u003cbr\u003e\u003cbr\u003eThe MKP-1 Polyclonal Antibody is supplied as a liquid formulation in a convenient size of 100 µg. It is provided in a ready-to-use format, eliminating the need for time-consuming antibody preparation steps. This antibody is suitable for use in both research and clinical settings, enabling accurate and reliable measurement of MKP-1 protein levels in a wide range of samples.\u003cbr\u003e\u003cbr\u003eIn summary, the MKP-1 Polyclonal Antibody is a valuable tool for researchers and clinicians studying the role of MKP-1 in various biological processes and diseases. Its high specificity, sensitivity, and ease of use make it an ideal choice for accurate detection and quantification of MKP-1 protein levels.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542220521752,"sku":"BT-AP05441","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_3126f791-69d6-4267-84c8-ab401a6fdd2a.png?v=1705628833","url":"https:\/\/danabiosci.com\/products\/new-product-569179","provider":"Dana Bioscience","version":"1.0","type":"link"}