{"product_id":"new-product-569154","title":"mGluR-8 Polyclonal Antibody","description":"\u003cp\u003eL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for GRM8.\u003c\/p\u003e\n\u003cp\u003eThe mGluR-8 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of metabotropic glutamate receptor 8 (mGluR-8) in various biological samples. This antibody is produced using high-quality polyclonal antibodies that have been purified and validated for use in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe mGluR-8 Polyclonal Antibody is a valuable tool for researchers studying the role of mGluR-8 in various physiological and pathological processes. This antibody has been extensively tested and validated for its specificity and sensitivity, ensuring accurate and reliable results in a variety of experimental settings.\u003cbr\u003e\u003cbr\u003eThe mGluR-8 Polyclonal Antibody is supplied in a convenient and easy-to-use format, making it an ideal choice for researchers looking for a reliable and effective antibody for their experiments. With its high specificity and sensitivity, this antibody is an essential tool for any researcher studying the function of mGluR-8 in the nervous system and beyond.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542217343256,"sku":"BT-AP05394","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_dfaf3363-e952-41c2-bced-e83fc48f122f.png?v=1705628675","url":"https:\/\/danabiosci.com\/products\/new-product-569154","provider":"Dana Bioscience","version":"1.0","type":"link"}