{"product_id":"new-product-569112","title":"MEK Kinase-3 Polyclonal Antibody","description":"\u003cp\u003eMAP3K3 product is a 626-amino acid polypeptide that is 96. % identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4. -kb transcript that appears to be ubiquitously expressed. Mitogen-activated protein kinase kinase kinase 3 directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1\/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.\u003c\/p\u003e\n\u003cp\u003eThe MEK Kinase-3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of MEK Kinase-3 protein expression in various biological samples. This antibody is produced using state-of-the-art techniques, ensuring high affinity and specificity for MEK Kinase-3.\u003cbr\u003e\u003cbr\u003eMEK Kinase-3, also known as MAP2K3, is a crucial component of the mitogen-activated protein kinase (MAPK) signaling pathway. It plays a pivotal role in cellular processes such as cell proliferation, differentiation, and apoptosis. Dysregulation of MEK Kinase-3 has been implicated in various diseases, including cancer, making it an important target for research and therapeutic development.\u003cbr\u003e\u003cbr\u003eThe MEK Kinase-3 Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of MEK Kinase-3 protein expression in both normal and diseased tissues.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The MEK Kinase-3 Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent and reproducible results.\u003cbr\u003e\u003cbr\u003eIn summary, the MEK Kinase-3 Polyclonal Antibody is a valuable tool for researchers studying the role of MEK Kinase-3 in cellular signaling pathways and disease processes. Its high specificity, sensitivity, and ease of use make it an ideal choice for a wide range of applications.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542206890264,"sku":"BT-AP05335","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_e73b0fef-d29a-40a7-9564-026a851b4c62.png?v=1705628415","url":"https:\/\/danabiosci.com\/products\/new-product-569112","provider":"Dana Bioscience","version":"1.0","type":"link"}