{"product_id":"new-product-569093","title":"MDM2 Polyclonal Antibody","description":"\u003cp\u003eMDM2 encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe MDM2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of MDM2 protein levels in various biological samples. This antibody is produced using a polyclonal approach, ensuring a diverse range of epitope recognition and enhanced sensitivity.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eMDM2, also known as Mouse Double Minute 2 homolog, is a crucial regulator of the p53 tumor suppressor pathway. It acts as an E3 ubiquitin ligase, promoting the degradation of p53 and inhibiting its transcriptional activity. Dysregulation of MDM2 has been implicated in various cancers, making it an important target for research and therapeutic development.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eThe MDM2 Polyclonal Antibody has been rigorously validated for its specificity and sensitivity through various experimental techniques, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other proteins, ensuring accurate and reliable results.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eThis antibody is supplied as a liquid formulation, ready for immediate use in various applications. It is provided in a convenient size, allowing for multiple experiments without compromising its quality. The MDM2 Polyclonal Antibody is suitable for use in both basic research and clinical studies, enabling researchers to gain valuable insights into the role of MDM2 in cancer development and progression.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eWith its exceptional performance and reliability, the MDM2 Polyclonal Antibody is an indispensable tool for scientists and clinicians working in the field of cancer biology and therapeutics. Its high specificity and sensitivity make it an ideal choice for studying MDM2 protein expression and its potential as a therapeutic target.\u003c\/span\u003e\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542202040600,"sku":"BT-AP05301","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_656ccf35-8d30-4a79-b04e-9ac08ba865fa.png?v=1705628299","url":"https:\/\/danabiosci.com\/products\/new-product-569093","provider":"Dana Bioscience","version":"1.0","type":"link"}