{"product_id":"new-product-568946","title":"LIMK-1\/2 Polyclonal Antibody","description":"\u003cp\u003eThere are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine\/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. LIM domain kinase 1 is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. LIM domain kinase 1 also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.\u003c\/p\u003e\n\u003cp\u003eThe LIMK-1\/2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of LIM domain kinase 1 and 2 proteins. This antibody is produced using advanced techniques to ensure high affinity and specificity, making it an ideal choice for various applications in research and diagnostics.\u003cbr\u003e\u003cbr\u003eThe LIMK-1\/2 Polyclonal Antibody exhibits exceptional performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) assays. It recognizes and binds to LIMK-1 and LIMK-2 proteins with high precision, enabling accurate and reliable results. This antibody has been extensively validated and optimized to provide consistent and reproducible outcomes.\u003cbr\u003e\u003cbr\u003eWith its superior sensitivity, the LIMK-1\/2 Polyclonal Antibody allows for the detection of low-abundance LIMK-1 and LIMK-2 proteins, even in complex biological samples. Its broad reactivity across multiple species ensures its versatility and applicability in various experimental settings.\u003cbr\u003e\u003cbr\u003eThe LIMK-1\/2 Polyclonal Antibody is manufactured under stringent quality control measures to ensure batch-to-batch consistency and reliability. It is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming preparation steps.\u003cbr\u003e\u003cbr\u003eIn summary, the LIMK-1\/2 Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of LIMK-1 and LIMK-2 proteins. Its exceptional performance, sensitivity, and versatility make it an indispensable asset for researchers and clinicians in the field of molecular biology and diagnostics.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542069264664,"sku":"BT-AP05019","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_b263e1a5-fc22-4f9f-b5cf-fc4f1aeb3aea.png?v=1705627592","url":"https:\/\/danabiosci.com\/products\/new-product-568946","provider":"Dana Bioscience","version":"1.0","type":"link"}