{"product_id":"new-product-568906","title":"Laminin Gamma-3 Polyclonal Antibody","description":"\u003cp\u003eLaminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. Alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. LAMC3 encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells.\u003c\/p\u003e\n\u003cp\u003eThe Laminin Gamma-3 Polyclonal Antibody is a highly specific and sensitive antibody that has been designed to detect and quantify the presence of Laminin Gamma-3 protein in various biological samples. This antibody has been extensively validated for use in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe Laminin Gamma-3 Polyclonal Antibody is produced using high-quality materials and state-of-the-art techniques, ensuring that it delivers consistent and reliable results. It has been rigorously tested to ensure that it is free from any non-specific binding or cross-reactivity with other proteins, making it an ideal tool for accurate and precise detection of Laminin Gamma-3.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied in a convenient and easy-to-use format, making it suitable for use in both research and diagnostic applications. It is available in a range of sizes to suit different experimental needs, and can be used in combination with other antibodies and reagents to achieve optimal results.\u003cbr\u003e\u003cbr\u003eOverall, the Laminin Gamma-3 Polyclonal Antibody is a valuable tool for researchers and clinicians working in the fields of cell biology, neuroscience, and cancer research, among others. Its high specificity, sensitivity, and reliability make it an essential component of any laboratory's toolkit.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542064447768,"sku":"BT-AP04947","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_900fe62a-9bc9-4c41-badb-917abb4c03e1.png?v=1705627393","url":"https:\/\/danabiosci.com\/products\/new-product-568906","provider":"Dana Bioscience","version":"1.0","type":"link"}