{"product_id":"new-product-568902","title":"Laminin Beta-2 Polyclonal Antibody","description":"\u003cp\u003eLaminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. Alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. LAMB2 encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known.\u003c\/p\u003e\n\u003cp\u003eThe Laminin Beta-2 Polyclonal Antibody is a highly specific and sensitive antibody that has been developed for the detection of Laminin Beta-2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Laminin Beta-2 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.\u003cbr\u003e\u003cbr\u003eThe Laminin Beta-2 Polyclonal Antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for use in human, mouse, and rat samples and has been shown to exhibit high specificity and sensitivity in detecting Laminin Beta-2 protein.\u003cbr\u003e\u003cbr\u003eThis antibody is an essential tool for researchers studying the role of Laminin Beta-2 protein in various biological processes, including cell adhesion, migration, and differentiation. It is also useful for diagnostic purposes, such as the detection of Laminin Beta-2 protein in cancer tissues.\u003cbr\u003e\u003cbr\u003eIn summary, the Laminin Beta-2 Polyclonal Antibody is a high-quality, reliable, and specific antibody that is essential for researchers and clinicians studying Laminin Beta-2 protein. Its sensitivity and specificity make it an ideal tool for a wide range of applications, including research and diagnostic purposes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542064054552,"sku":"BT-AP04943","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_92e23201-b800-41af-82e9-da0746a83f99.png?v=1705627369","url":"https:\/\/danabiosci.com\/products\/new-product-568902","provider":"Dana Bioscience","version":"1.0","type":"link"}