{"product_id":"new-product-568892","title":"Lamin A\/C Polyclonal Antibody","description":"\u003cp\u003eThe nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in LMNA lead to several diseases: emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.\u003c\/p\u003e\n\u003cp\u003eThe Lamin A\/C Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Lamin A\/C protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards Lamin A\/C.\u003cbr\u003e\u003cbr\u003eLamin A\/C is a key component of the nuclear lamina, a network of intermediate filaments that provides structural support to the nucleus. It plays a crucial role in maintaining nuclear integrity, regulating gene expression, and participating in various cellular processes such as DNA replication and repair. Dysregulation of Lamin A\/C has been implicated in several human diseases, including muscular dystrophy, cardiomyopathy, and premature aging syndromes.\u003cbr\u003e\u003cbr\u003eThe Lamin A\/C Polyclonal Antibody exhibits exceptional performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications. It recognizes both the mature Lamin A and Lamin C isoforms, enabling comprehensive analysis of Lamin A\/C expression and localization in different cell types and tissues.\u003cbr\u003e\u003cbr\u003eThis antibody has been rigorously validated using a wide range of experimental approaches, ensuring reliable and reproducible results. It exhibits minimal cross-reactivity with other lamin isoforms, ensuring specific detection of Lamin A\/C without interference from closely related proteins.\u003cbr\u003e\u003cbr\u003eThe Lamin A\/C Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation. It is provided in a convenient format, allowing for easy storage and handling. Each batch of antibody undergoes stringent quality control procedures to ensure consistent performance and batch-to-batch reproducibility.\u003cbr\u003e\u003cbr\u003eIn summary, the Lamin A\/C Polyclonal Antibody is a highly reliable and versatile tool for the investigation of Lamin A\/C protein expression and localization. Its exceptional specificity, sensitivity, and ease of use make it an ideal choice for researchers studying nuclear structure and function, as well as those investigating the role of Lamin A\/C in various disease processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542062416152,"sku":"BT-AP04933","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_8c916e90-7063-4986-9b22-a4b0ca63ef68.png?v=1705627308","url":"https:\/\/danabiosci.com\/products\/new-product-568892","provider":"Dana Bioscience","version":"1.0","type":"link"}