{"product_id":"new-product-568864","title":"Ku-70 (Acetyl Lys542) Polyclonal Antibody","description":"\u003cp\u003eThe p70\/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.\u003c\/p\u003e\n\u003cp\u003eThe Ku-70 (Acetyl Lys542) Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of Ku-70 protein acetylation at lysine 542. This antibody has been meticulously developed and rigorously validated to ensure optimal performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe Ku-70 protein plays a crucial role in DNA repair and maintenance of genomic stability. Acetylation of lysine 542 has been shown to regulate the function of Ku-70, thereby influencing its involvement in DNA repair processes. The Ku-70 (Acetyl Lys542) Polyclonal Antibody specifically recognizes and binds to the acetylated form of Ku-70 at lysine 542, enabling researchers to investigate the impact of this post-translational modification on cellular processes.\u003cbr\u003e\u003cbr\u003eThis antibody exhibits exceptional sensitivity and specificity, ensuring accurate and reliable results. It has been extensively validated using various experimental approaches, including peptide blocking, knockdown\/knockout validation, and positive control validation. The Ku-70 (Acetyl Lys542) Polyclonal Antibody demonstrates minimal cross-reactivity with other acetylated lysine residues, further enhancing its specificity.\u003cbr\u003e\u003cbr\u003eWith its superior performance characteristics, the Ku-70 (Acetyl Lys542) Polyclonal Antibody is an invaluable tool for researchers studying DNA repair mechanisms and cellular responses to DNA damage. Its versatility and reliability make it suitable for a wide range of applications, facilitating in-depth investigations into the role of Ku-70 acetylation in various biological processes.\u003cbr\u003e\u003cbr\u003eOrder the Ku-70 (Acetyl Lys542) Polyclonal Antibody today and unlock new insights into the intricate mechanisms governing DNA repair and maintenance of genomic stability.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542048882968,"sku":"BT-AP04889","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_51d91941-b8cc-4ca5-83b3-ee8e90ad36fb.png?v=1705627156","url":"https:\/\/danabiosci.com\/products\/new-product-568864","provider":"Dana Bioscience","version":"1.0","type":"link"}