{"product_id":"new-product-568821","title":"KDEL Receptor 2 Polyclonal Antibody","description":"\u003cp\u003eRetention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms.\u003c\/p\u003e\n\u003cp\u003eThe KDEL Receptor 2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of KDEL receptor 2 protein expression. This antibody is produced using advanced techniques to ensure high affinity and specificity, making it an ideal choice for various applications in research and diagnostics.\u003cbr\u003e\u003cbr\u003eThe KDEL receptor 2 is a crucial component of the endoplasmic reticulum (ER) retrieval system, responsible for the retrieval of ER-resident proteins that have escaped to the Golgi apparatus. It plays a vital role in maintaining ER homeostasis and protein quality control. Dysregulation of the KDEL receptor 2 has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.\u003cbr\u003e\u003cbr\u003eOur KDEL Receptor 2 Polyclonal Antibody has been extensively validated for its performance in various experimental settings. It exhibits exceptional sensitivity and specificity, enabling accurate detection and quantification of KDEL receptor 2 protein levels. This antibody has been tested and validated in a wide range of sample types, including cell lysates, tissue lysates, and whole-cell extracts.\u003cbr\u003e\u003cbr\u003eThe KDEL Receptor 2 Polyclonal Antibody is manufactured using state-of-the-art production techniques, ensuring batch-to-batch consistency and reproducibility. It is purified to the highest standards, resulting in a highly pure and concentrated antibody preparation. This antibody is provided in a convenient liquid format, ready for immediate use in various applications, including Western blotting, immunohistochemistry, immunofluorescence, and flow cytometry.\u003cbr\u003e\u003cbr\u003eWith its exceptional performance and versatility, the KDEL Receptor 2 Polyclonal Antibody is an indispensable tool for researchers and clinicians studying the role of KDEL receptor 2 in cellular processes and disease pathogenesis. Its high specificity and sensitivity make it an invaluable asset for elucidating the molecular mechanisms underlying ER homeostasis and protein quality control. Trust in the reliability and performance of our KDEL Receptor 2 Polyclonal Antibody to advance your research and diagnostic endeavors.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542035415320,"sku":"BT-AP04779","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_db90812e-07ff-4a4d-89f7-ff055e373d97.png?v=1705626932","url":"https:\/\/danabiosci.com\/products\/new-product-568821","provider":"Dana Bioscience","version":"1.0","type":"link"}