Histone H3 (Tri Methyl Lys18) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H3A (histone cluster 1 H3 family member a) is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. HIST1H3A is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H3 (Tri Methyl Lys18) Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of histone H3 protein modifications. This antibody is designed to specifically recognize and bind to the tri methylated lysine 18 residue on histone H3, allowing for the precise identification and quantification of this specific modification.

The Histone H3 (Tri Methyl Lys18) Polyclonal Antibody has been extensively validated and characterized for its high affinity and specificity towards the tri methylated lysine 18 modification. It has been rigorously tested in various applications, including Western blotting, immunoprecipitation, and immunofluorescence, ensuring reliable and reproducible results.

This antibody is produced using a polyclonal approach, resulting in a diverse population of antibodies that recognize different epitopes on the target protein. This allows for increased sensitivity and robustness in detecting the tri methylated lysine 18 modification of histone H3.

The Histone H3 (Tri Methyl Lys18) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and complex antibody preparation. It is provided in a convenient format, allowing for easy integration into existing experimental protocols.

With its exceptional specificity, sensitivity, and ease of use, the Histone H3 (Tri Methyl Lys18) Polyclonal Antibody is an invaluable tool for researchers studying histone modifications and their role in various biological processes.