{"product_id":"new-product-568398","title":"Histone H3 (Mono Methyl Lys4) Polyclonal Antibody","description":"\u003cp\u003eHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H3A (histone cluster 1 H3 family member a) is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. HIST1H3A is found in the large histone gene cluster on chromosome 6p22-p21.3.\u003c\/p\u003e\n\u003cp\u003eThe Histone H3 (Mono Methyl Lys4) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of histone H3 mono-methylated at lysine 4. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target antigen.\u003cbr\u003e\u003cbr\u003eHistone H3 is a crucial component of chromatin, playing a vital role in gene regulation and chromatin structure. Methylation of lysine 4 on histone H3 has been implicated in various biological processes, including transcriptional activation and gene expression. The mono-methylation of lysine 4 is a key modification that can influence chromatin accessibility and facilitate the recruitment of transcriptional regulators.\u003cbr\u003e\u003cbr\u003eThe Histone H3 (Mono Methyl Lys4) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and chromatin immunoprecipitation. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of histone H3 mono-methylated at lysine 4 in various biological samples.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation, allowing for easy handling and convenient use. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps. The antibody is suitable for use in both research and diagnostic applications, making it an invaluable tool for scientists and clinicians alike.\u003cbr\u003e\u003cbr\u003eWith its exceptional performance, high specificity, and ease of use, the Histone H3 (Mono Methyl Lys4) Polyclonal Antibody is an essential reagent for studying the role of histone modifications in gene regulation and chromatin dynamics.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541773173016,"sku":"BT-AP04067","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_35bf29cb-8801-45a3-90dc-8638f1ccb31e.png?v=1705624541","url":"https:\/\/danabiosci.com\/products\/new-product-568398","provider":"Dana Bioscience","version":"1.0","type":"link"}