{"product_id":"new-product-568394","title":"Histone H3 (Mono Methyl Lys18) Polyclonal Antibody","description":"\u003cp\u003eHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H3A (histone cluster 1 H3 family member a) is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. HIST1H3A is found in the large histone gene cluster on chromosome 6p22-p21.3.\u003c\/p\u003e\n\u003cp\u003eThe Histone H3 (Mono Methyl Lys18) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of histone H3 mono-methylated at lysine 18. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target antigen.\u003cbr\u003e\u003cbr\u003eHistone H3 is a crucial component of chromatin, playing a vital role in gene regulation and chromatin structure. Lysine 18 mono-methylation of histone H3 has been implicated in various biological processes, including transcriptional activation and DNA repair. Therefore, the ability to accurately detect and quantify this modification is of utmost importance in understanding the underlying mechanisms of these processes.\u003cbr\u003e\u003cbr\u003eThis polyclonal antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling reliable and reproducible results. Additionally, this antibody has been extensively tested for cross-reactivity with other histone modifications and has shown minimal to no cross-reactivity, ensuring accurate and specific detection of histone H3 mono-methylated at lysine 18.\u003cbr\u003e\u003cbr\u003eThe Histone H3 (Mono Methyl Lys18) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is provided in a convenient format, allowing for easy storage and handling. Each batch of this antibody undergoes stringent quality control measures to ensure consistent performance and reliability.\u003cbr\u003e\u003cbr\u003eIn summary, the Histone H3 (Mono Methyl Lys18) Polyclonal Antibody is a valuable tool for researchers studying histone modifications and their role in various biological processes. Its high specificity, sensitivity, and ease of use make it an ideal choice for accurate detection and analysis of histone H3 mono-methylated at lysine 18.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541770682648,"sku":"BT-AP04063","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_003560fa-df8a-480f-b19c-5a1bdd369e8c.png?v=1705624519","url":"https:\/\/danabiosci.com\/products\/new-product-568394","provider":"Dana Bioscience","version":"1.0","type":"link"}