{"product_id":"new-product-568342","title":"Histone H2A Polyclonal Antibody","description":"\u003cp\u003eHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. HIST1H2AI is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.\u003c\/p\u003e\n\u003cp\u003eThe Histone H2A Polyclonal Antibody is a highly specific and sensitive antibody that has been developed for the detection of Histone H2A protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the N-terminal region of human Histone H2A protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.\u003cbr\u003e\u003cbr\u003eThe Histone H2A Polyclonal Antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for use in human, mouse, and rat samples and has been shown to exhibit minimal cross-reactivity with other histone proteins. The antibody has a high affinity for Histone H2A protein and can detect both the phosphorylated and unphosphorylated forms of the protein.\u003cbr\u003e\u003cbr\u003eThis antibody is an essential tool for researchers studying epigenetics, chromatin structure, and gene regulation. It can be used to investigate the role of Histone H2A in various cellular processes, including DNA replication, repair, and transcription. The Histone H2A Polyclonal Antibody is a reliable and sensitive reagent that can provide valuable insights into the complex mechanisms of gene expression and regulation.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541750858008,"sku":"BT-AP03999","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_13858a7c-8719-4cef-8a06-5c3de43d1380.png?v=1705624205","url":"https:\/\/danabiosci.com\/products\/new-product-568342","provider":"Dana Bioscience","version":"1.0","type":"link"}