{"product_id":"new-product-568218","title":"GR Polyclonal Antibody","description":"\u003cp\u003eNR3C1 encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in NR3C1 are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID: 15866175).\u003c\/p\u003e\n\u003cp\u003eThe GR Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of the glucocorticoid receptor (GR) protein in various biological samples. This antibody is produced using a polyclonal approach, ensuring a diverse range of antibodies that recognize different epitopes of the GR protein. \u003cbr\u003e\u003cbr\u003eThe GR Polyclonal Antibody exhibits exceptional affinity and selectivity towards the GR protein, enabling accurate and reliable results in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its high sensitivity allows for the detection of low levels of GR protein, making it an ideal choice for studies requiring precise quantification.\u003cbr\u003e\u003cbr\u003eThis antibody is manufactured using state-of-the-art techniques and undergoes rigorous quality control measures to ensure consistent performance and batch-to-batch reproducibility. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation.\u003cbr\u003e\u003cbr\u003eThe GR Polyclonal Antibody is compatible with various sample types, including cell lysates, tissue extracts, and serum, making it suitable for a wide range of research areas, such as endocrinology, neuroscience, and cancer biology. Its versatility and reliability make it an indispensable tool for scientists and researchers seeking to investigate the role of the GR protein in various physiological and pathological processes.\u003cbr\u003e\u003cbr\u003eIn summary, the GR Polyclonal Antibody offers exceptional sensitivity, specificity, and versatility, making it an invaluable asset for researchers in need of a reliable tool for the detection and quantification of the glucocorticoid receptor protein.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541690302744,"sku":"BT-AP03790","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_5899159b-674e-4c46-b244-cc89e1600977.png?v=1705623515","url":"https:\/\/danabiosci.com\/products\/new-product-568218","provider":"Dana Bioscience","version":"1.0","type":"link"}