{"product_id":"new-product-568094","title":"GluR-Delta2 Polyclonal Antibody","description":"\u003cp\u003eThe glutamate ionotropic receptor delta type subunit 2 encoded by GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.\u003c\/p\u003e\n\u003cp\u003eThe GluR-Delta2 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of GluR-Delta2 protein expression in various biological samples. This antibody has been meticulously developed and validated to ensure exceptional performance and accuracy in a wide range of applications, including immunohistochemistry, western blotting, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe GluR-Delta2 Polyclonal Antibody exhibits a high affinity and selectivity towards GluR-Delta2, a subunit of the glutamate receptor family that plays a crucial role in synaptic plasticity and neuronal development. With its exceptional sensitivity, this antibody enables the precise identification and quantification of GluR-Delta2 expression levels, facilitating comprehensive investigations into the functional significance of this protein in various physiological and pathological processes.\u003cbr\u003e\u003cbr\u003eThis antibody has been rigorously tested and validated using a variety of experimental approaches, ensuring its reliability and reproducibility. It exhibits minimal cross-reactivity with other glutamate receptor subunits, guaranteeing specific and accurate detection of GluR-Delta2. Furthermore, it demonstrates excellent performance in various sample types, including tissue sections, cell lysates, and cultured cells.\u003cbr\u003e\u003cbr\u003eThe GluR-Delta2 Polyclonal Antibody is supplied as a highly purified and concentrated solution, ensuring optimal performance and ease of use. It is provided in a convenient format, allowing for flexible and efficient experimental design. Additionally, this antibody is compatible with a wide range of detection systems and can be used in combination with other antibodies for multiplex analysis.\u003cbr\u003e\u003cbr\u003eIn summary, the GluR-Delta2 Polyclonal Antibody is a valuable tool for researchers studying the role of GluR-Delta2 in synaptic plasticity, neuronal development, and related processes. Its exceptional specificity, sensitivity, and reliability make it an indispensable asset for a wide range of applications in the field of neuroscience and beyond.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541634138392,"sku":"BT-AP03602","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_8eaa957f-d794-4130-9d2a-45db8996e955.png?v=1705622814","url":"https:\/\/danabiosci.com\/products\/new-product-568094","provider":"Dana Bioscience","version":"1.0","type":"link"}