{"product_id":"new-product-568049","title":"GDF-5 Polyclonal Antibody","description":"\u003cp\u003eGDF5 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Growth\/differentiation factor 5 regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis.\u003c\/p\u003e\n\u003cp\u003eThe GDF-5 Polyclonal Antibody is a highly specific and sensitive antibody that has been developed for the detection of Growth Differentiation Factor 5 (GDF-5) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human GDF-5 protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and is suitable for use in various applications, including Western blotting, immunohistochemistry, and ELISA.\u003cbr\u003e\u003cbr\u003eThe GDF-5 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in detecting GDF-5 protein in various tissues and cell lines. It has been shown to recognize both the mature and precursor forms of GDF-5 protein, and does not cross-react with other members of the TGF-β superfamily. This antibody has also been shown to be highly reproducible and reliable, providing consistent results across multiple experiments.\u003cbr\u003e\u003cbr\u003eThe GDF-5 Polyclonal Antibody is supplied as a liquid in phosphate-buffered saline (PBS) containing 0.02% sodium azide as a preservative. It is available in various sizes to meet the needs of different applications and experimental designs. This antibody is an essential tool for researchers studying the role of GDF-5 in various biological processes, including skeletal development, joint formation, and cartilage repair.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541609824536,"sku":"BT-AP03530","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_90f0d818-ca99-4512-b483-3a643190feb0.png?v=1705622552","url":"https:\/\/danabiosci.com\/products\/new-product-568049","provider":"Dana Bioscience","version":"1.0","type":"link"}