{"product_id":"new-product-567554","title":"E2F-4 Polyclonal Antibody","description":"\u003cp\u003eTranscription factor E2F4 encoded by E2F4 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.\u003c\/p\u003e\n\u003cp\u003eThe E2F-4 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of E2F-4 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein. \u003cbr\u003e\u003cbr\u003eE2F-4 is a transcription factor that plays a crucial role in cell cycle regulation and cell proliferation. It is involved in the control of genes required for DNA replication and cell division. Dysregulation of E2F-4 expression has been implicated in various diseases, including cancer. Therefore, accurate detection and quantification of E2F-4 protein levels are essential for understanding its biological functions and its potential as a therapeutic target.\u003cbr\u003e\u003cbr\u003eThe E2F-4 Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling reliable and reproducible results. This antibody recognizes endogenous levels of E2F-4 protein in a wide range of species, including human, mouse, and rat.\u003cbr\u003e\u003cbr\u003eFurthermore, the E2F-4 Polyclonal Antibody is manufactured under strict quality control standards to ensure batch-to-batch consistency and reproducibility. It is supplied as a liquid formulation, ready to use for immediate application. The antibody is provided in a convenient size and format, allowing for easy handling and storage.\u003cbr\u003e\u003cbr\u003eIn summary, the E2F-4 Polyclonal Antibody is a valuable tool for researchers studying cell cycle regulation, cell proliferation, and related diseases. Its high specificity, sensitivity, and versatility make it an ideal choice for various experimental techniques. With its reliable performance and consistent quality, this antibody is an essential component for any laboratory conducting research in this field.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541407416600,"sku":"BT-AP02793","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_7b2b2d81-9e4e-49f5-9d4f-9f59e0e3cad3.png?v=1705619006","url":"https:\/\/danabiosci.com\/products\/new-product-567554","provider":"Dana Bioscience","version":"1.0","type":"link"}