{"product_id":"new-product-567502","title":"Dok-3 Polyclonal Antibody","description":"\u003cp\u003eDok-1, Dok-2 and Dok-3 are members of a class of \"docking\" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl. Dok-3 is an adapter involved in the recruitment of inhibitory molecules and is highly expressed in B cells and macrophages. Immunoreceptor-mediated cellular activation induces tyrosine phosphorylation of Dok-3. Upon phosphorylation, Dok-3 binds to 5' inositol phosphatase SHIP and the protein tyrosine kinase Csk. Dok-3 may play a significant role in the negative regulation of immunoreceptor signaling in hemopoietic cells.\u003c\/p\u003e\n\u003cp\u003eThe Dok-3 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of Dok-3 protein expression in various biological samples. This antibody has been meticulously developed and rigorously validated to ensure optimal performance and accuracy in experimental settings.\u003cbr\u003e\u003cbr\u003eThe Dok-3 Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling precise identification and quantification of Dok-3 protein levels. It is designed to recognize endogenous levels of Dok-3 protein, making it an invaluable asset for researchers studying the role and function of Dok-3 in cellular processes.\u003cbr\u003e\u003cbr\u003eThis antibody is produced using state-of-the-art techniques, ensuring batch-to-batch consistency and reproducibility. It has been extensively tested in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence, demonstrating its versatility and reliability across different experimental platforms.\u003cbr\u003e\u003cbr\u003eThe Dok-3 Polyclonal Antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps. The antibody is also available in different sizes to accommodate various experimental requirements.\u003cbr\u003e\u003cbr\u003eWith its exceptional performance characteristics and robust validation, the Dok-3 Polyclonal Antibody is an indispensable tool for researchers investigating the intricate mechanisms underlying cellular signaling pathways involving Dok-3. Its high specificity and sensitivity make it an ideal choice for accurate and reliable detection of Dok-3 protein expression in diverse biological samples.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541392867608,"sku":"BT-AP02699","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_3774c66c-9edc-498e-80b1-58b91f96fd19.png?v=1705618731","url":"https:\/\/danabiosci.com\/products\/new-product-567502","provider":"Dana Bioscience","version":"1.0","type":"link"}