{"product_id":"new-product-567272","title":"CYP11B1\/2 Polyclonal Antibody","description":"\u003cp\u003eCYP11B1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for CYP11B1.\u003c\/p\u003e\n\u003cp\u003eThe CYP11B1\/2 Polyclonal Antibody is a highly specific and sensitive antibody designed for use in various research applications. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CYP11B1\/2 protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and is suitable for use in Western blotting, immunohistochemistry, and ELISA assays.\u003cbr\u003e\u003cbr\u003eThe CYP11B1\/2 Polyclonal Antibody is a valuable tool for researchers studying the function and regulation of the CYP11B1\/2 protein. This protein is a member of the cytochrome P450 family of enzymes and is involved in the biosynthesis of steroid hormones such as cortisol and aldosterone. Dysregulation of CYP11B1\/2 activity has been implicated in a variety of diseases, including hypertension, adrenal hyperplasia, and adrenal carcinoma.\u003cbr\u003e\u003cbr\u003eThis antibody has been extensively validated for specificity and sensitivity in a variety of experimental conditions. It has been shown to recognize both CYP11B1 and CYP11B2 isoforms of the protein in human, mouse, and rat tissues. The antibody has also been shown to be highly specific, with no cross-reactivity with other cytochrome P450 enzymes or unrelated proteins.\u003cbr\u003e\u003cbr\u003eIn summary, the CYP11B1\/2 Polyclonal Antibody is a high-quality reagent that is ideal for researchers studying the function and regulation of the CYP11B1\/2 protein. Its high specificity and sensitivity make it a valuable tool for a wide range of applications, including Western blotting, immunohistochemistry, and ELISA assays.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541318058264,"sku":"BT-AP02376","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_c718d1bf-e669-4276-83c6-e5b00b9593bc.png?v=1705617489","url":"https:\/\/danabiosci.com\/products\/new-product-567272","provider":"Dana Bioscience","version":"1.0","type":"link"}