{"product_id":"new-product-567235","title":"CUL-4B Polyclonal Antibody","description":"\u003cp\u003eCUL4B is a member of the cullin family. The cullin 4B forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe CUL-4B Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of CUL-4B protein expression in various biological samples. This antibody has been meticulously developed using advanced immunization techniques and exhibits exceptional sensitivity and specificity.\u003cbr\u003e\u003cbr\u003eCUL-4B, also known as Cullin-4B, is a crucial component of the Cullin-RING E3 ubiquitin ligase complex. It plays a pivotal role in regulating protein degradation and turnover by targeting specific substrates for ubiquitination and subsequent proteasomal degradation. Dysregulation of CUL-4B has been implicated in various pathological conditions, including cancer, neurodevelopmental disorders, and intellectual disabilities.\u003cbr\u003e\u003cbr\u003eThe CUL-4B Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent reactivity across a wide range of species, including human, mouse, and rat, making it a versatile tool for diverse research needs.\u003cbr\u003e\u003cbr\u003eThis antibody is manufactured using high-quality materials and undergoes rigorous quality control measures to ensure batch-to-batch consistency and reproducibility. It is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage.\u003cbr\u003e\u003cbr\u003eIn summary, the CUL-4B Polyclonal Antibody is a reliable and specific tool for the detection and analysis of CUL-4B protein expression. Its exceptional performance and versatility make it an invaluable asset for researchers studying the intricate mechanisms of protein degradation and its implications in various diseases.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541307670808,"sku":"BT-AP02319","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_2a332d02-3fe5-46eb-b529-6aac8a861296.png?v=1705617291","url":"https:\/\/danabiosci.com\/products\/new-product-567235","provider":"Dana Bioscience","version":"1.0","type":"link"}