{"product_id":"new-product-567233","title":"CUL-2 Polyclonal Antibody","description":"\u003cp\u003eCullin proteins comprise a distinct family of mediators that participate in the selective targeting of proteins for ubiquitin (Ub)-mediated proteolysis. CUL-1, which is the mammalian homolog of yeast Cdc53, is an integral component of the E3 ubiquitin ligase complex designated SCF. The SCF (Skp1\/CUL-1\/F-box protein complex) consists of Skp1 associating with both CUL-1 and an F-box protein, such as Skp2, which determines the substrate specificity of the complex. CUL-1-mediated ubiquitination results in the degradation of cell cycle proteins cyclin D, p21 and cyclin E. Another cullin, CUL-3, facilitates the degradation of cyclin E independent of SCF activity, while CUL-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes, which structurally resemble the SCF ligase. Proteolysis also occurs by way of CUL-4 associating with Nedd-8, a ubiquitin-like protein, where it too functions as an active component of a multifunctional E3 complex. CUL-5, also designated vasopressin-activated, calcium-mobilizing protein (VACM-1), is also included in the cullin family as it shares substantial sequence homology with CUL-1.\u003c\/p\u003e\n\u003cp\u003eThe CUL-2 Polyclonal Antibody is a highly specific and sensitive antibody designed for use in various research applications. This antibody is produced using high-quality materials and advanced techniques to ensure optimal performance and reliability. It is designed to target the CUL-2 protein, which is a key component of the Cullin-RING E3 ubiquitin ligase complex. The CUL-2 Polyclonal Antibody is suitable for use in Western blotting, immunohistochemistry, and other applications where high specificity and sensitivity are required.\u003c\/p\u003e\n\u003cp\u003eIt is supplied in a convenient format and is ready to use with minimal preparation. This antibody is an essential tool for researchers studying the role of CUL-2 in various cellular processes and diseases. With its exceptional performance and reliability, the CUL-2 Polyclonal Antibody is an excellent choice for any research project requiring high-quality antibodies.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541306556696,"sku":"BT-AP02316","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_155e9592-aef9-4e5c-b972-17b85b4d77b0.png?v=1705617279","url":"https:\/\/danabiosci.com\/products\/new-product-567233","provider":"Dana Bioscience","version":"1.0","type":"link"}