{"product_id":"new-product-567011","title":"Cleaved-Thrombin APII (R327) Polyclonal Antibody","description":"\u003cp\u003eCoagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\u003cp\u003eThe CLN6 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of CLN6 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CLN6 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards CLN6 protein, making it an ideal tool for various research applications.\u003cbr\u003e\u003cbr\u003eThe CLN6 Polyclonal Antibody is suitable for use in a variety of immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been validated for use in human, mouse, and rat samples, and has been shown to detect endogenous levels of CLN6 protein in various tissues and cell lines. This antibody is also suitable for use in studies investigating the role of CLN6 protein in various biological processes, including lysosomal function and neurodegeneration.\u003cbr\u003e\u003cbr\u003eThe CLN6 Polyclonal Antibody is supplied as a purified IgG fraction, and is available in various sizes to suit different experimental needs. It is recommended for use at a dilution of 1:1000 for Western blotting, and 1:200 for immunohistochemistry. This antibody is also suitable for use in combination with other antibodies and reagents for multiplexed detection of multiple proteins in a single sample.\u003cbr\u003e\u003cbr\u003eOverall, the CLN6 Polyclonal Antibody is a reliable and versatile tool for the detection and quantification of CLN6 protein in various biological samples. Its high specificity and sensitivity make it an ideal choice for researchers studying lysosomal function and neurodegeneration, as well as those investigating the role of CLN6 protein in other biological processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541238661400,"sku":"BT-AP01966","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_4cc1e9ed-e543-4b2f-85bf-986a3d5661d8.png?v=1705615982","url":"https:\/\/danabiosci.com\/products\/new-product-567011","provider":"Dana Bioscience","version":"1.0","type":"link"}