{"product_id":"new-product-566999","title":"Cleaved-Notch 2 (A1734) Polyclonal Antibody","description":"\u003cp\u003eNOTCH2 encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions.\u003c\/p\u003e\n\u003cp\u003eThe Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined.\u003c\/p\u003e\n\u003cp\u003eThe notch 2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. The notch 2 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe Cleaved-Notch 2 (A1734) Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of cleaved Notch 2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the cleaved Notch 2 protein sequence and purified using a combination of protein A and peptide affinity chromatography techniques.\u003c\/p\u003e\n\u003cp\u003eThe Cleaved-Notch 2 (A1734) Polyclonal Antibody exhibits excellent specificity and sensitivity, with minimal cross-reactivity to other proteins. It is suitable for use in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is recommended to store the antibody at -20°C for long-term storage and avoid repeated freeze-thaw cycles.\u003c\/p\u003e\n\u003cp\u003eThe Cleaved-Notch 2 (A1734) Polyclonal Antibody is an essential tool for researchers studying the Notch signaling pathway and its role in various physiological and pathological processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541236007192,"sku":"BT-AP01954","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_d1323cc5-1a3a-4a10-8a74-24687a00be75.png?v=1705615910","url":"https:\/\/danabiosci.com\/products\/new-product-566999","provider":"Dana Bioscience","version":"1.0","type":"link"}