{"product_id":"new-product-566991","title":"Cleaved-MMP-14 (Y112) Polyclonal Antibody","description":"\u003cp\u003eProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by MMP14 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. Matrix metallopeptidase 14 activates MMP2 protein, and this activity may be involved in tumor invasion.\u003c\/p\u003e\n\u003cp\u003eThe Cleaved-MMP-14 (Y112) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of cleaved matrix metalloproteinase-14 (MMP-14) in various biological samples. This antibody is produced using advanced techniques, ensuring exceptional quality and performance.\u003cbr\u003e\u003cbr\u003eMatrix metalloproteinase-14, also known as membrane-type 1 matrix metalloproteinase (MT1-MMP), plays a crucial role in extracellular matrix remodeling and cell migration. Cleavage of MMP-14 at the Y112 site is a key event in its activation and regulation. Therefore, the Cleaved-MMP-14 (Y112) Polyclonal Antibody is an invaluable resource for investigating the activation and function of MMP-14 in physiological and pathological processes.\u003cbr\u003e\u003cbr\u003eThis antibody exhibits high specificity towards the cleaved form of MMP-14, enabling accurate detection and quantification of the active enzyme. It has been extensively validated in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. The Cleaved-MMP-14 (Y112) Polyclonal Antibody demonstrates excellent sensitivity and minimal cross-reactivity, ensuring reliable and reproducible results.\u003cbr\u003e\u003cbr\u003eFurthermore, this antibody is produced using state-of-the-art purification techniques, resulting in a highly purified and concentrated product. It is supplied in a convenient format, allowing for easy handling and storage. The Cleaved-MMP-14 (Y112) Polyclonal Antibody is suitable for use in both research and clinical applications, making it an indispensable tool for scientists and clinicians alike.\u003cbr\u003e\u003cbr\u003eIn summary, the Cleaved-MMP-14 (Y112) Polyclonal Antibody is a superior reagent that offers exceptional specificity, sensitivity, and reliability for the detection and analysis of cleaved MMP-14. Its high-quality production and versatile applications make it an essential component of any study or diagnostic assay involving MMP-14 activation and function.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541232927000,"sku":"BT-AP01946","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_164bc2c5-d76c-4835-b243-414d911d5e55.png?v=1705615865","url":"https:\/\/danabiosci.com\/products\/new-product-566991","provider":"Dana Bioscience","version":"1.0","type":"link"}