{"product_id":"new-product-566990","title":"Cleaved-MMP-12 (G106) Polyclonal Antibody","description":"\u003cp\u003eMMP12 encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Matrix metallopeptidase 12 degrades soluble and insoluble elastin. MMP12 may play a role in aneurysm formation and mutations MMP12 are associated with lung function and chronic obstructive pulmonary disease (COPD). MMP12 is part of a cluster of MMP genes on chromosome 11.\u003c\/p\u003e\n\u003cp\u003eThe Cleaved-MMP-12 (G106) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of cleaved matrix metalloproteinase-12 (MMP-12) in various biological samples. This antibody has been meticulously developed using advanced immunization techniques, resulting in a high affinity and specificity towards the cleaved form of MMP-12.\u003cbr\u003e\u003cbr\u003eMatrix metalloproteinase-12, also known as macrophage elastase, plays a crucial role in tissue remodeling and inflammation. The cleaved form of MMP-12 is of particular interest as it is associated with various pathological conditions, including chronic obstructive pulmonary disease (COPD), emphysema, and atherosclerosis. Accurate detection and quantification of cleaved MMP-12 is essential for understanding the underlying mechanisms of these diseases and developing targeted therapeutic interventions.\u003cbr\u003e\u003cbr\u003eThe Cleaved-MMP-12 (G106) Polyclonal Antibody exhibits exceptional sensitivity and selectivity, enabling precise detection of cleaved MMP-12 even at low concentrations. It has been extensively validated for use in various immunoassays, including Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assays (ELISA). This antibody demonstrates minimal cross-reactivity with other MMP isoforms, ensuring reliable and specific results.\u003cbr\u003e\u003cbr\u003eFurthermore, the Cleaved-MMP-12 (G106) Polyclonal Antibody is produced using high-quality materials and stringent quality control measures. Each batch is rigorously tested to ensure consistent performance, reliability, and reproducibility. The antibody is supplied in a convenient format, allowing for easy handling and storage.\u003cbr\u003e\u003cbr\u003eIn summary, the Cleaved-MMP-12 (G106) Polyclonal Antibody is a valuable tool for researchers and clinicians involved in studying MMP-12-related diseases. Its exceptional sensitivity, specificity, and reliability make it an indispensable asset for accurate detection and quantification of cleaved MMP-12 in various biological samples.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541232730392,"sku":"BT-AP01945","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_bda1a0c2-aa6e-42b8-b5e6-ddec13f47b70.png?v=1705615860","url":"https:\/\/danabiosci.com\/products\/new-product-566990","provider":"Dana Bioscience","version":"1.0","type":"link"}