{"product_id":"new-product-566985","title":"Cleaved-Lamin A (D230) Polyclonal Antibody","description":"\u003cp\u003eThe nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in LMNA lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.\u003c\/p\u003e\n\u003cp\u003eThe Cleaved-Lamin A (D230) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of cleaved-Lamin A protein in various biological samples. This antibody has been meticulously developed and validated to ensure exceptional performance and accuracy in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe Cleaved-Lamin A (D230) Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling the precise identification and quantification of cleaved-Lamin A protein. It recognizes a specific epitope within the cleaved region of Lamin A, allowing for the discrimination between cleaved and intact forms of the protein. This antibody has been extensively tested and validated using various cell lines and tissues, ensuring its reliability and reproducibility.\u003cbr\u003e\u003cbr\u003eWith its high affinity and selectivity, the Cleaved-Lamin A (D230) Polyclonal Antibody offers researchers a valuable tool for investigating the role of cleaved-Lamin A in various cellular processes and disease states. Its robust performance and versatility make it suitable for a wide range of research applications, including studies on aging, cancer, and cellular senescence.\u003cbr\u003e\u003cbr\u003eThe Cleaved-Lamin A (D230) Polyclonal Antibody is produced using state-of-the-art techniques and undergoes rigorous quality control measures to ensure consistent and reliable results. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation.\u003cbr\u003e\u003cbr\u003eIn summary, the Cleaved-Lamin A (D230) Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of cleaved-Lamin A protein. Its exceptional sensitivity, specificity, and versatility make it an invaluable asset for researchers in various fields, enabling them to gain deeper insights into the role of cleaved-Lamin A in cellular processes and disease mechanisms.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541230797080,"sku":"BT-AP01940","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_d8271952-5da5-4ca9-88f5-ea61aaba7dd4.png?v=1705615822","url":"https:\/\/danabiosci.com\/products\/new-product-566985","provider":"Dana Bioscience","version":"1.0","type":"link"}