{"product_id":"new-product-566971","title":"Cleaved-Factor XII HC (R372) Polyclonal Antibody","description":"\u003cp\u003eF12 encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in F12 do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.\u003c\/p\u003e\n\u003cp\u003eIntroducing the Cleaved-Factor XII HC (R372) Polyclonal Antibody, a cutting-edge immunological tool meticulously designed to facilitate advanced research in the field of coagulation. This high-quality antibody is specifically tailored to detect and target the cleaved form of Factor XII HC (R372), a crucial protein involved in the intricate cascade of blood clotting.\u003cbr\u003e\u003cbr\u003eCrafted with utmost precision, this polyclonal antibody exhibits exceptional specificity and sensitivity, enabling accurate identification and quantification of cleaved-Factor XII HC (R372) in various biological samples. Its robust performance ensures reliable and reproducible results, empowering researchers to delve deeper into the mechanisms underlying coagulation disorders and related pathologies.\u003cbr\u003e\u003cbr\u003eThe Cleaved-Factor XII HC (R372) Polyclonal Antibody boasts an extensive range of applications, including but not limited to immunohistochemistry, western blotting, and enzyme-linked immunosorbent assays (ELISA). Its versatility allows for comprehensive investigations across diverse experimental setups, facilitating comprehensive characterization of cleaved-Factor XII HC (R372) expression patterns and dynamics.\u003cbr\u003e\u003cbr\u003eThis antibody is meticulously manufactured using state-of-the-art techniques, guaranteeing batch-to-batch consistency and exceptional quality control. Rigorous testing ensures optimal performance, minimizing non-specific binding and cross-reactivity, thereby enhancing the accuracy and reliability of experimental outcomes.\u003cbr\u003e\u003cbr\u003eFurthermore, the Cleaved-Factor XII HC (R372) Polyclonal Antibody is supplied in a user-friendly format, conveniently packaged and ready for immediate use. Its long shelf life and stability ensure prolonged usability, making it an indispensable asset for laboratories and research institutions alike.\u003cbr\u003e\u003cbr\u003eIn summary, the Cleaved-Factor XII HC (R372) Polyclonal Antibody represents a breakthrough in coagulation research, offering researchers an invaluable tool to unravel the complexities of Factor XII HC (R372) cleavage. With its exceptional specificity, sensitivity, and versatility, this antibody empowers scientists to advance their understanding of coagulation disorders and pave the way for novel therapeutic interventions.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541229224216,"sku":"BT-AP01926","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_af253e1b-14db-4d74-bd63-145792582138.png?v=1705615747","url":"https:\/\/danabiosci.com\/products\/new-product-566971","provider":"Dana Bioscience","version":"1.0","type":"link"}