{"product_id":"new-product-566950","title":"Cleaved-Caspase-9 (D353) Polyclonal Antibody","description":"\u003cp\u003eCASP9 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 9 can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. Caspase 9 is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\u003cp\u003eThe Cleaved-Caspase-9 (D353) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of cleaved caspase-9 in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional performance and reliability.\u003cbr\u003e\u003cbr\u003eCaspase-9 is a crucial enzyme involved in the initiation of apoptosis, a programmed cell death process essential for maintaining tissue homeostasis. The cleaved form of caspase-9 (D353) is a key indicator of caspase-9 activation, making it an invaluable marker for studying apoptotic pathways and evaluating the efficacy of anti-cancer therapies.\u003cbr\u003e\u003cbr\u003eOur Cleaved-Caspase-9 (D353) Polyclonal Antibody exhibits exceptional specificity, binding exclusively to the cleaved form of caspase-9 without cross-reactivity to the full-length protein or other caspase family members. This high specificity ensures accurate and reliable results, minimizing false positives and false negatives.\u003cbr\u003e\u003cbr\u003eFurthermore, this antibody demonstrates outstanding sensitivity, enabling the detection of low levels of cleaved caspase-9 in even the most challenging samples. Its superior sensitivity allows for precise quantification and analysis, facilitating comprehensive investigations into apoptotic processes.\u003cbr\u003e\u003cbr\u003eThe Cleaved-Caspase-9 (D353) Polyclonal Antibody has been extensively validated in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. Its exceptional performance in these applications ensures its versatility and suitability for a wide range of research purposes.\u003cbr\u003e\u003cbr\u003eIn addition to its exceptional performance, this antibody is manufactured to the highest quality standards. Each batch undergoes rigorous quality control procedures to guarantee consistency and reproducibility. Its long shelf life and stability ensure reliable results over an extended period, minimizing the need for frequent reordering.\u003cbr\u003e\u003cbr\u003eIn summary, the Cleaved-Caspase-9 (D353) Polyclonal Antibody is a highly specific, sensitive, and reliable tool for the detection and quantification of cleaved caspase-9. Its exceptional performance, versatility, and quality make it an indispensable asset for researchers studying apoptotic pathways and evaluating therapeutic interventions.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541224866072,"sku":"BT-AP01905","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_5058f35a-392e-4053-9092-b526f9f184c7.png?v=1705615642","url":"https:\/\/danabiosci.com\/products\/new-product-566950","provider":"Dana Bioscience","version":"1.0","type":"link"}