{"product_id":"new-product-566948","title":"Cleaved-Caspase-8 p18 (S217) Polyclonal Antibody","description":"\u003cp\u003eCASP8 (caspase 8) encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved\u003c\/p\u003e\n\u003cp\u003einternal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.\u003c\/p\u003e\n\u003cp\u003eThe Cleaved-Caspase-8 p18 (S217) Polyclonal Antibody is a highly specific and sensitive tool for the detection of cleaved caspase-8 p18 (S217) in various biological samples. This antibody is produced using high-quality polyclonal antibodies that have been rigorously tested for specificity and sensitivity. The Cleaved-Caspase-8 p18 (S217) Polyclonal Antibody is designed to recognize the cleaved form of caspase-8 p18 (S217) and is suitable for use in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence. This antibody is ideal for researchers studying apoptosis and cell death pathways, as well as those investigating the role of caspase-8 in various disease states. With its high specificity and sensitivity, the Cleaved-Caspase-8 p18 (S217) Polyclonal Antibody is an essential tool for any researcher working in the field of cell biology.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541224767768,"sku":"BT-AP01903","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_0d327a5e-bf02-4594-95cc-f3333fb89fc2.png?v=1705615633","url":"https:\/\/danabiosci.com\/products\/new-product-566948","provider":"Dana Bioscience","version":"1.0","type":"link"}