{"product_id":"new-product-566947","title":"Cleaved-Caspase-8 (D384) Polyclonal Antibody","description":"\u003cp\u003eCASP8 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD. Caspase 8 was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.\u003c\/p\u003e\n\u003cp\u003eThe Cleaved-Caspase-8 (D384) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of cleaved caspase-8 protein in various biological samples. This antibody has been meticulously developed using advanced immunization techniques and exhibits exceptional affinity and selectivity towards the target protein.\u003cbr\u003e\u003cbr\u003eCaspase-8 is a crucial enzyme involved in the initiation of apoptosis, a programmed cell death process. Cleavage of caspase-8 at the D384 site is a key event in the activation of this enzyme, leading to the subsequent cascade of apoptotic events. Therefore, the detection and measurement of cleaved caspase-8 (D384) is of paramount importance in understanding the apoptotic pathway and its dysregulation in various diseases.\u003cbr\u003e\u003cbr\u003eThe Cleaved-Caspase-8 (D384) Polyclonal Antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other caspase family members, ensuring accurate and reliable results.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation, ready for immediate use in various applications. It is compatible with a wide range of sample types, including cell lysates, tissue homogenates, and biological fluids. The Cleaved-Caspase-8 (D384) Polyclonal Antibody is provided in a convenient size and concentration, allowing for cost-effective and efficient experimentation.\u003cbr\u003e\u003cbr\u003eWith its exceptional performance characteristics, the Cleaved-Caspase-8 (D384) Polyclonal Antibody is an indispensable tool for researchers and scientists studying apoptosis and its implications in various pathological conditions. Its high specificity, sensitivity, and reliability make it an ideal choice for both basic research and clinical applications.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541224669464,"sku":"BT-AP01902","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_ad01b10c-c1f1-4048-9b44-159a11150497.png?v=1705615626","url":"https:\/\/danabiosci.com\/products\/new-product-566947","provider":"Dana Bioscience","version":"1.0","type":"link"}