{"product_id":"new-product-566938","title":"Cleaved-Caspase-4\/5 p20 (D270\/D311) Polyclonal Antibody","description":"\u003cp\u003eCASP4 (caspase 4) encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, caspase 4 induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.\u003c\/p\u003e\n\u003cp\u003eThe Cleaved-Caspase-4\/5 p20 (D270\/D311) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of cleaved Caspase-4 and Caspase-5 p20 fragments in various biological samples. This antibody is produced using advanced techniques, ensuring high affinity and specificity towards the target protein.\u003cbr\u003e\u003cbr\u003eCaspase-4 and Caspase-5 are key enzymes involved in the apoptotic pathway, playing crucial roles in programmed cell death. The cleaved p20 fragments of these caspases are indicative of their activation and are widely used as biomarkers for apoptosis research.\u003cbr\u003e\u003cbr\u003eThe Cleaved-Caspase-4\/5 p20 (D270\/D311) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been rigorously validated to provide reliable and reproducible results, making it an ideal choice for both basic research and clinical investigations.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and error-prone reconstitution steps. The antibody is also available in different sizes to accommodate various experimental requirements.\u003cbr\u003e\u003cbr\u003eWith its exceptional sensitivity and specificity, the Cleaved-Caspase-4\/5 p20 (D270\/D311) Polyclonal Antibody is an indispensable tool for researchers and clinicians studying apoptosis and related processes. Its reliable performance and ease of use make it an invaluable asset in advancing our understanding of cellular mechanisms and developing potential therapeutic interventions.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541221097752,"sku":"BT-AP01893","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_c4588438-f529-4ea4-8a19-0f3a9ba7f53d.png?v=1705615571","url":"https:\/\/danabiosci.com\/products\/new-product-566938","provider":"Dana Bioscience","version":"1.0","type":"link"}