{"product_id":"new-product-566920","title":"CLC-4 Polyclonal Antibody","description":"\u003cp\u003eThe CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. CLCN4 is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins.\u003c\/p\u003e\n\u003cp\u003eThe Claudin-3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Claudin-3 protein expression in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and batch-to-batch consistency.\u003cbr\u003e\u003cbr\u003eClaudin-3 is a key component of tight junctions, playing a crucial role in maintaining the integrity and barrier function of epithelial and endothelial cell layers. Dysregulation of Claudin-3 expression has been implicated in various pathological conditions, including cancer progression and metastasis.\u003cbr\u003e\u003cbr\u003eThe Claudin-3 Polyclonal Antibody exhibits exceptional specificity, binding exclusively to Claudin-3 protein without cross-reactivity to other Claudin family members. It has been extensively validated in multiple experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThis antibody demonstrates superior sensitivity, enabling the detection of low levels of Claudin-3 protein expression. Its robust performance ensures reliable and accurate results, making it an ideal choice for both basic research and clinical applications.\u003cbr\u003e\u003cbr\u003eThe Claudin-3 Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is available in various sizes to accommodate different experimental requirements.\u003cbr\u003e\u003cbr\u003eWith its exceptional specificity, sensitivity, and reliability, the Claudin-3 Polyclonal Antibody is an indispensable tool for researchers and clinicians studying the role of Claudin-3 in various physiological and pathological processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541216444696,"sku":"BT-AP01860","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_ad68aa91-2a89-41e0-83bb-affbc4d04802.png?v=1705615472","url":"https:\/\/danabiosci.com\/products\/new-product-566920","provider":"Dana Bioscience","version":"1.0","type":"link"}