{"product_id":"new-product-566919","title":"Claudin-8 Polyclonal Antibody","description":"\u003cp\u003eCLDN8 (claudin 8) encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of CLDN8 has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.\u003c\/p\u003e\n\u003cp\u003eThe Claudin-8 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Claudin-8 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards Claudin-8.\u003cbr\u003e\u003cbr\u003eClaudin-8 is a crucial component of tight junctions, which play a vital role in maintaining the integrity and barrier function of epithelial and endothelial cell layers. Dysregulation of Claudin-8 expression has been implicated in various pathological conditions, including cancer, inflammation, and neurological disorders. Therefore, the accurate detection and quantification of Claudin-8 protein levels are of utmost importance in understanding its functional significance and potential therapeutic implications.\u003cbr\u003e\u003cbr\u003eThe Claudin-8 Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for its specificity and sensitivity, ensuring reliable and reproducible results. This antibody recognizes endogenous Claudin-8 protein in a wide range of species, making it a versatile tool for researchers working with different model organisms.\u003cbr\u003e\u003cbr\u003eWith its high-quality formulation and optimized protocols, the Claudin-8 Polyclonal Antibody offers researchers a valuable tool to investigate the role of Claudin-8 in various physiological and pathological processes. Its exceptional performance and reliability make it an indispensable asset for studies focused on tight junction biology, epithelial barrier function, and related research areas.\u003cbr\u003e\u003cbr\u003eOrder the Claudin-8 Polyclonal Antibody today and unlock new insights into the intricate mechanisms underlying Claudin-8-mediated cellular processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541216411928,"sku":"BT-AP01854","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_07b186a0-ff8e-4099-9055-a350a0a27246.png?v=1705615469","url":"https:\/\/danabiosci.com\/products\/new-product-566919","provider":"Dana Bioscience","version":"1.0","type":"link"}