{"product_id":"new-product-566887","title":"CIITA Polyclonal Antibody","description":"\u003cp\u003eCIITA encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the \"master control factor\" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe CIITA Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of the Class II Major Histocompatibility Complex (MHC) Transactivator (CIITA) protein. This antibody is meticulously produced using advanced techniques to ensure exceptional quality and performance.\u003cbr\u003e\u003cbr\u003eThe CIITA Polyclonal Antibody exhibits a high affinity towards the CIITA protein, enabling accurate and sensitive detection in various experimental applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its exceptional specificity ensures minimal cross-reactivity with other proteins, guaranteeing reliable and precise results.\u003cbr\u003e\u003cbr\u003eThis antibody is meticulously validated to meet the highest standards of quality and consistency. Rigorous quality control measures are implemented throughout the production process to ensure batch-to-batch reproducibility and reliability. Each lot of the CIITA Polyclonal Antibody undergoes thorough testing to ensure optimal performance, providing researchers with confidence in their experimental outcomes.\u003cbr\u003e\u003cbr\u003eThe CIITA Polyclonal Antibody is supplied in a convenient and user-friendly format, allowing for easy handling and storage. It is provided in a liquid form, eliminating the need for reconstitution, and is available in various sizes to accommodate different experimental requirements.\u003cbr\u003e\u003cbr\u003eWith its exceptional specificity, reliability, and ease of use, the CIITA Polyclonal Antibody is an indispensable tool for researchers studying the Class II MHC Transactivator protein. Its superior performance and consistent results make it an ideal choice for a wide range of applications in the field of immunology and molecular biology.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541207138584,"sku":"BT-AP01805","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_79a4e24d-f41b-4cc9-baa5-e97c50e0c85f.png?v=1705615274","url":"https:\/\/danabiosci.com\/products\/new-product-566887","provider":"Dana Bioscience","version":"1.0","type":"link"}