{"product_id":"new-product-566865","title":"Chk2 Polyclonal Antibody","description":"\u003cp\u003eIn response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The checkpoint kinase 2 encoded by CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine\/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe Chk2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Chk2 protein expression in various biological samples. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards Chk2 protein.\u003cbr\u003e\u003cbr\u003eThe Chk2 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It enables researchers to accurately quantify and visualize Chk2 protein levels in cell lysates, tissue sections, and cultured cells.\u003cbr\u003e\u003cbr\u003eWith its superior sensitivity, this antibody allows for the detection of low-abundance Chk2 protein, making it an ideal choice for studies requiring precise quantification. Its robust performance ensures reliable and reproducible results, facilitating accurate data interpretation and analysis.\u003cbr\u003e\u003cbr\u003eThe Chk2 Polyclonal Antibody is manufactured under stringent quality control measures, ensuring batch-to-batch consistency and reliability. It is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming antibody preparation.\u003cbr\u003e\u003cbr\u003eIn summary, the Chk2 Polyclonal Antibody is a valuable tool for researchers investigating Chk2 protein expression and its role in various biological processes. Its high specificity, sensitivity, and versatility make it an indispensable asset in the field of molecular biology and cancer research.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541202092312,"sku":"BT-AP01769","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_5e0ea3a0-4118-427d-9aaa-beede1e0c073.png?v=1705615133","url":"https:\/\/danabiosci.com\/products\/new-product-566865","provider":"Dana Bioscience","version":"1.0","type":"link"}