{"product_id":"new-product-566676","title":"CD40 Polyclonal Antibody","description":"\u003cp\u003eCD40 is a member of the TNF-receptor superfamily. The encoded protein (CD40 molecule) is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.\u003c\/p\u003e\n\u003cp\u003eThe CD40 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of CD40 protein expression in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the extracellular domain of human CD40 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards CD40 protein, making it an ideal tool for a wide range of applications in research and diagnostics.\u003cbr\u003e\u003cbr\u003eThe CD40 Polyclonal Antibody is suitable for use in various immunoassays, including Western blotting, immunohistochemistry, and flow cytometry. It has been validated for use in human, mouse, and rat samples, and has been shown to detect CD40 protein expression in a variety of tissues and cell types. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.\u003cbr\u003e\u003cbr\u003eThe CD40 Polyclonal Antibody is a reliable and versatile tool for the study of CD40 protein expression in various biological systems. Its high specificity and sensitivity make it an essential reagent for researchers and clinicians working in the fields of immunology, oncology, and infectious diseases. With its excellent performance and ease of use, this antibody is an excellent choice for any laboratory looking to investigate the role of CD40 in health and disease.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541139865880,"sku":"BT-AP01500","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_04355a1f-65d6-40a8-a209-c6cc27475e2a.png?v=1705614096","url":"https:\/\/danabiosci.com\/products\/new-product-566676","provider":"Dana Bioscience","version":"1.0","type":"link"}