{"product_id":"new-product-566664","title":"CD35 Polyclonal Antibody","description":"\u003cp\u003eCR1 (complement C3b\/C4b receptor 1 (Knops blood group)) is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. CR1 encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and\/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in CR1 have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.\u003c\/p\u003e\n\u003cp\u003eThe CD35 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of CD35 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CD35 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards CD35 protein, making it an ideal tool for various research applications.\u003cbr\u003e\u003cbr\u003eThe CD35 Polyclonal Antibody is suitable for use in a variety of immunoassays, including Western blotting, immunohistochemistry, and flow cytometry. It has been validated for use in human, mouse, and rat samples, and has been shown to detect CD35 protein in a variety of tissues and cell types. This antibody is supplied as a liquid formulation, and is ready-to-use for most applications.\u003cbr\u003e\u003cbr\u003eThe CD35 Polyclonal Antibody is a valuable tool for researchers studying the role of CD35 protein in various biological processes, including immune response, inflammation, and complement activation. Its high sensitivity and specificity make it an ideal reagent for both basic research and clinical applications. With its reliable performance and ease of use, the CD35 Polyclonal Antibody is an essential tool for any laboratory studying CD35 protein.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541122695448,"sku":"BT-AP01487","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_70b6a288-21f7-44e8-97b6-22520b17b98b.png?v=1705614017","url":"https:\/\/danabiosci.com\/products\/new-product-566664","provider":"Dana Bioscience","version":"1.0","type":"link"}