{"product_id":"new-product-566648","title":"CD30-L Polyclonal Antibody","description":"\u003cp\u003eCD30 ligand (CD30L)\/TNFSF8 is a type II membrane protein belonging to the TNF superfamily. CD30L is expressed on the cell surface of activated T cells, B cells, and monocytes. The protein is also constitutively expressed on granulocytes and medullary thymic epithelial cells. The specific receptor for CD30L is CD30\/TNFRSF8, a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkin's and Reed-Sternberg cells using the monoclonal antibody Ki-1. CD30 is also expressed on different non-Hodgkin's lymphomas, virus-infected T and B cells, and on normal T and B cells after activation. Among T cells, CD30 is preferentially expressed on a subset of T cells producing Th2-type cytokines and on CD4+\/CD8+ thymocytes that coexpress CD45RO and IL-4 receptor. CD30 ligation by CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation and cell death by apoptosis. CD30 can act as a costimulatory molecule in thymic negative selection and may also play a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. Human and mouse CD30 ligand cDNAs share 70% sequence homology.\u003c\/p\u003e\n\u003cp\u003eThe CD30-L Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and analysis of CD30-L protein expression in various biological samples. This antibody is produced through a rigorous purification process, ensuring high purity and quality. \u003cbr\u003e\u003cbr\u003eCD30-L, also known as CD153, is a type II transmembrane protein belonging to the tumor necrosis factor (TNF) superfamily. It is primarily expressed on activated T cells, B cells, and dendritic cells. CD30-L plays a crucial role in immune regulation, particularly in T cell-dependent B cell activation and differentiation. \u003cbr\u003e\u003cbr\u003eThe CD30-L Polyclonal Antibody exhibits exceptional affinity and specificity towards CD30-L, enabling accurate and reliable detection of this protein in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting applications. It has been extensively validated for its performance in various experimental settings, ensuring consistent and reproducible results.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps. The CD30-L Polyclonal Antibody is compatible with a wide range of sample types, including formalin-fixed paraffin-embedded (FFPE) tissues, frozen sections, and cell culture samples.\u003cbr\u003e\u003cbr\u003eWith its exceptional sensitivity and specificity, the CD30-L Polyclonal Antibody is an indispensable tool for researchers and clinicians involved in the study of immune regulation, cancer biology, and autoimmune diseases. Its reliable performance and ease of use make it an ideal choice for a wide range of applications, facilitating accurate and insightful analysis of CD30-L protein expression.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541120303384,"sku":"BT-AP01466","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_5dd47210-3049-4bdb-ad56-412668518351.png?v=1705613948","url":"https:\/\/danabiosci.com\/products\/new-product-566648","provider":"Dana Bioscience","version":"1.0","type":"link"}