{"product_id":"new-product-566571","title":"CD158a Polyclonal Antibody","description":"\u003cp\u003eKiller cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13. within the 1 Mb leukocyte receptor complex (LRC).\u003c\/p\u003e\n\u003cp\u003eThe gene content of the KIR gene cluster varies among haplotypes, although several \"framework\" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals.\u003c\/p\u003e\n\u003cp\u003eThe ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.\u003c\/p\u003e\n\u003cp\u003eThe CD158a Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of CD158a protein expression in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the extracellular domain of human CD158a protein.\u003c\/p\u003e\n\u003cp\u003eThe resulting polyclonal antibody exhibits high affinity and specificity towards CD158a protein, making it an ideal tool for various research applications, including Western blotting, immunohistochemistry, and flow cytometry. The CD158a Polyclonal Antibody is supplied as a purified and lyophilized product, ensuring consistent and reliable performance. With its exceptional sensitivity and specificity, this antibody is an essential tool for researchers studying the role of CD158a protein in various physiological and pathological processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47541089829144,"sku":"BT-AP01363","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_abd0e964-2ea7-4eb0-a137-f9fff4728d96.png?v=1705613518","url":"https:\/\/danabiosci.com\/products\/new-product-566571","provider":"Dana Bioscience","version":"1.0","type":"link"}